On each level, the goal is to kill aliens while locating a teleporter randomly placed on the level once the teleporter is activated, the players must defend themselves from a larger onslaught of aliens, including bosses, until the teleporter is fully charged. Risk of Rain 2 features several of the same playable characters, creatures, and items from the first game, but also adds new survivors and most notably transitions the game from 2D to a 3D environment. Each survivor has their own unique set of skills, providing different approaches to gameplay based on which survivor the player chooses. There are a total of fourteen survivors, two of which are only available in the Survivors of the Void expansion. Most survivors are locked until the player completes challenges pertaining to each one the only survivors available at first are the Commando and Huntress.

Risk of Rain 2 follows a similar approach to the first title, in which one to four players must progress several levels while killing enemies. The game received generally positive reviews upon release. The game supports up to four players in online multiplayer. Over time, the game's difficulty increases, spawning more powerful and dangerous creatures. To survive, they navigate through various environments, killing monsters and looting chests to collect items that boost their offensive and defensive capabilities. Players control a survivor who is stranded on an alien planet.

A sequel to 2013's Risk of Rain, it was released in early access for Microsoft Windows, Nintendo Switch, PlayStation 4 and Xbox One in 2019 before fully releasing in August 2020 with a release for Stadia coming a month later. Risk of Rain 2 is a roguelike third-person shooter developed by Hopoo Games and published by Gearbox Publishing. Microsoft Windows, Switch, PlayStation 4, and Xbox One

Risk engine